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Table 2 Calculated counts for analyte sensitivity comparisons

From: Experimental vitamin B12 deficiency in a human subject: a longitudinal investigation of the performance of the holotranscobalamin (HoloTC, Active-B12) immunoassay

Figure Count criteria Reference Quadrant Count
1b Concurrent B12 and HoloTC tests (N)    95
1b B12 ≥162 pmol/L and HoloTC ≥35 pmol/L L 1 94
1b B12 ≥295 pmol/L and HoloTC ≥35 pmol/L A 1 41
1b B12 ≥133 pmol/L and HoloTC ≥35 pmol/L B 1 94
1b B12 ≥162 pmol/L and HoloTC <35 pmol/L L 2 1
1b B12 ≥295 pmol/L and HoloTC <35 pmol/L A 2 0
1b B12 ≥133 pmol/L and HoloTC <35 pmol/L B 2 1
1b B12 <162 pmol/L and HoloTC <35 pmol/L L 3 0
1b B12 <295 pmol/L and HoloTC <35 pmol/L A 3 1
1b B12 <133 pmol/L and HoloTC <35 pmol/L B 3 0
1b B12 <162 pmol/L and HoloTC ≥35 pmol/L L 4 0
1b B12 <295 pmol/L and HoloTC ≥35 pmol/L A 4 53
1b B12 <133 pmol/L and HoloTC ≥35 pmol/L B 4 0
2b Concurrent MMA and HoloTC Tests (N)    52
2b MMA ≥0.34 µmol/L and HoloTC ≥35 pmol/L L 1 23
2b MMA ≥0.34 µmol/L and HoloTC <35 pmol/L L 2 1
2b MMA <0.34 µmol/L and HoloTC <35 pmol/L L 3 0
2b MMA <0.34 µmol/L and HoloTC ≥35 pmol/L L 4 28
3b Concurrent tHcy and HoloTC tests (N)    52
3b tHcy ≥13.7 µmol/L and HoloTC ≥35 pmol/L L 1 1
3b tHcy ≥13.7 µmol/L and HoloTC <35 pmol/L L 2 0
3b tHcy <13.7 µmol/L and HoloTC <35 pmol/L L 3 1
3b tHcy <13.7 µmol/L and HoloTC ≥35 pmol/L L 4 50
4b Concurrent MMA and B12 tests (N)    55
4b MMA ≥0.34 µmol/L and B12 ≥162 pmol/L L 1 24
4b MMA ≥0.34 µmol/L and B12 ≥295 pmol/L A 1 1
4b MMA ≥0.34 µmol/L and B12 ≥133 pmol/L B 1 24
4b MMA <0.34 µmol/L and B12 ≥162 pmol/L L 2 31
4b MMA <0.34 µmol/L and B12 ≥295 pmol/L A 2 20
4b MMA <0.34 µmol/L and B12 ≥133 pmol/L B 2 31
4b MMA <0.34 µmol/L and B12 <162 pmol/L L 3 0
4b MMA <0.34 µmol/L and B12 <295 pmol/L A 3 11
4b MMA <0.34 µmol/L and B12 <133 pmol/L B 3 0
4b MMA ≥0.34 µmol/L and B12 <162 pmol/L L 4 0
4b MMA ≥0.34 µmol/L and B12 <295 pmol/L A 4 23
4b MMA ≥0.34 µmol/L and B12 <133 pmol/L B 4 0
  1. Reference L = analyte concentration limit defined by the testing laboratory, reference A = analyte concentration limit defined by Oh and Brown (2003), reference B = analyte concentration limit defined by Bates and Lewis (2012), Quadrant = chart quadrant: , Count = number of concurrent analyte pair concentration results within each quadrant