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Table 2 Calculated counts for analyte sensitivity comparisons

From: Experimental vitamin B12 deficiency in a human subject: a longitudinal investigation of the performance of the holotranscobalamin (HoloTC, Active-B12) immunoassay

Figure

Count criteria

Reference

Quadrant

Count

1b

Concurrent B12 and HoloTC tests (N)

  

95

1b

B12 ≥162 pmol/L and HoloTC ≥35 pmol/L

L

1

94

1b

B12 ≥295 pmol/L and HoloTC ≥35 pmol/L

A

1

41

1b

B12 ≥133 pmol/L and HoloTC ≥35 pmol/L

B

1

94

1b

B12 ≥162 pmol/L and HoloTC <35 pmol/L

L

2

1

1b

B12 ≥295 pmol/L and HoloTC <35 pmol/L

A

2

0

1b

B12 ≥133 pmol/L and HoloTC <35 pmol/L

B

2

1

1b

B12 <162 pmol/L and HoloTC <35 pmol/L

L

3

0

1b

B12 <295 pmol/L and HoloTC <35 pmol/L

A

3

1

1b

B12 <133 pmol/L and HoloTC <35 pmol/L

B

3

0

1b

B12 <162 pmol/L and HoloTC ≥35 pmol/L

L

4

0

1b

B12 <295 pmol/L and HoloTC ≥35 pmol/L

A

4

53

1b

B12 <133 pmol/L and HoloTC ≥35 pmol/L

B

4

0

2b

Concurrent MMA and HoloTC Tests (N)

  

52

2b

MMA ≥0.34 µmol/L and HoloTC ≥35 pmol/L

L

1

23

2b

MMA ≥0.34 µmol/L and HoloTC <35 pmol/L

L

2

1

2b

MMA <0.34 µmol/L and HoloTC <35 pmol/L

L

3

0

2b

MMA <0.34 µmol/L and HoloTC ≥35 pmol/L

L

4

28

3b

Concurrent tHcy and HoloTC tests (N)

  

52

3b

tHcy ≥13.7 µmol/L and HoloTC ≥35 pmol/L

L

1

1

3b

tHcy ≥13.7 µmol/L and HoloTC <35 pmol/L

L

2

0

3b

tHcy <13.7 µmol/L and HoloTC <35 pmol/L

L

3

1

3b

tHcy <13.7 µmol/L and HoloTC ≥35 pmol/L

L

4

50

4b

Concurrent MMA and B12 tests (N)

  

55

4b

MMA ≥0.34 µmol/L and B12 ≥162 pmol/L

L

1

24

4b

MMA ≥0.34 µmol/L and B12 ≥295 pmol/L

A

1

1

4b

MMA ≥0.34 µmol/L and B12 ≥133 pmol/L

B

1

24

4b

MMA <0.34 µmol/L and B12 ≥162 pmol/L

L

2

31

4b

MMA <0.34 µmol/L and B12 ≥295 pmol/L

A

2

20

4b

MMA <0.34 µmol/L and B12 ≥133 pmol/L

B

2

31

4b

MMA <0.34 µmol/L and B12 <162 pmol/L

L

3

0

4b

MMA <0.34 µmol/L and B12 <295 pmol/L

A

3

11

4b

MMA <0.34 µmol/L and B12 <133 pmol/L

B

3

0

4b

MMA ≥0.34 µmol/L and B12 <162 pmol/L

L

4

0

4b

MMA ≥0.34 µmol/L and B12 <295 pmol/L

A

4

23

4b

MMA ≥0.34 µmol/L and B12 <133 pmol/L

B

4

0

  1. Reference L = analyte concentration limit defined by the testing laboratory, reference A = analyte concentration limit defined by Oh and Brown (2003), reference B = analyte concentration limit defined by Bates and Lewis (2012), Quadrant = chart quadrant: , Count = number of concurrent analyte pair concentration results within each quadrant