Fig. 1

PRISMA diagram representing screening process and final trial eligibility. ^aSome trial records did not have a primary completion date (n = 246). These trials were deemed not likely to meet the cut-off date and excluded from the database if they met the following criteria: (1) possessed a completion date before January 2012 (n = 112); (2) had completed, terminated or withdrawn status and their records were last verified before January 2012 (n = 37); (3) were not verified by the sponsor in more than 10 years (n = 18); 4) possessed a start date before 1998 (n = 19); ^bTrials in mixed populations were also excluded. BC breast cancer