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Table 4 Factors associated with Disease Free Survival—overall population

From: Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer: an observational study

  Univariate HR (95 % CI) p value Multivariate HR (95 % CI) p value
Age (increase of 10 years) 0.74 (0.56–0.97) 0.027 0.83 (0.63–1.10) 0.194
Tumor size (increase of 10 mm) 1.33 (0.98–1.81) 0.064 1.01 (0.68–1.49) 0.961
Histological grade     
 Grade 1 (reference) 1   1  
 Grade 2 2.03 (0.59–7.01) 0.264 1.84 (0.52–6.56) 0.347
 Grade 3 5.73 (1.73–19.04) 0.004 2.39 (0.62–9.17) 0.205
Subtype     
 Luminal A 1    
 Luminal B 2.11 (0.95–4.73) 0.067 1.62 (0.69–3.79) 0.267
 HER2 5.68 (2.18–14.74) 0.0004 3.88 (1.34–11.25) 0.013
 Triple negative 9.36 (4.04–21.67) <.0001 5.94 (2.09–16.85) 0.0008
SLN positivity     
 No metastasis 1    
 Positive metastasis 1.68 (0.89–3.16) 0.108   
SLN pattern     
 No metastasis 1    
 Micrometastasis 1.72 (0.71–4.18) 0.230   
 Macrometastasis 1.65 (0.77–3.51) 0.193   
Presence of LVI (yes vs. no) 1.84 (0.98–3.44) 0.057 1.19 (0.60–2.33) 0.622
  1. SLN Sentinel Lymph Node, LVI LymphoVascular Invasion