Table 4 Factors associated with Disease Free Survival—overall population

Age (increase of 10 years)

0.74 (0.56–0.97)

0.027

0.83 (0.63–1.10)

0.194

Tumor size (increase of 10 mm)

1.33 (0.98–1.81)

0.064

1.01 (0.68–1.49)

0.961

Histological grade

 Grade 1 (reference)

1

1

 Grade 2

2.03 (0.59–7.01)

0.264

1.84 (0.52–6.56)

0.347

 Grade 3

5.73 (1.73–19.04)

0.004

2.39 (0.62–9.17)

0.205

Subtype

 Luminal A

1

 Luminal B

2.11 (0.95–4.73)

0.067

1.62 (0.69–3.79)

0.267

 HER2

5.68 (2.18–14.74)

0.0004

3.88 (1.34–11.25)

0.013

 Triple negative

9.36 (4.04–21.67)

<.0001

5.94 (2.09–16.85)

0.0008

SLN positivity

 No metastasis

1

 Positive metastasis

1.68 (0.89–3.16)

0.108

SLN pattern

 No metastasis

1

 Micrometastasis

1.72 (0.71–4.18)

0.230

 Macrometastasis

1.65 (0.77–3.51)

0.193

Presence of LVI (yes vs. no)

1.84 (0.98–3.44)

0.057

1.19 (0.60–2.33)

0.622