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Table 3 Factors associated with sentinel node status

From: Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer: an observational study

  Overall sample (N = 345) Luminal subgroup (N = 297)
Univariate OR (95 % CI) p value Multivariate OR (95 % CI) p value Univariate OR (95 % CI) p value Multivariate OR (95 % CI) p value
Age (increase of 10 years) 0.98 (0.79–1.22) 0.880    0.93 (0.74–1.18) 0.552   
Menopausal status (pre vs. post) 1.23 (0.68–2.20) 0.495    1.28 (0.68–2.42) 0.450   
Number of excised sentinel nodes (continuous variable) 1.06 (0.81–1.39) 0.656    1.08 (0.80–1.44) 0.627   
Histology         
 Ductal (reference) 1 0.127    1 0.205   
 Lobular 1.02 (0.51–2.03)     1.06 (0.52–2.14)    
 Mixed 1.45 (0.76–2.77)     1.24 (0.63–2.46)    
 Others 0.30 (0.09–1.01)     0.13 (0.02–0.98)    
 Tumor size (increase of 10 mm) 1.56 (1.14–2.13) 0.005 1.20 (0.86–1.68) 0.289 1.71 (1.19–2.45) 0.004 1.22 (0.84–1.78) 0.307
Subtype         
 Luminal A (reference) 1     1 0.215   
 Luminal B 1.39 (0.81–2.37) 0.232    1.41 (0.82–2.40)    
 HER2 2.16 (0.84–5.57) 0.111       
 Triple negative 0.46 (0.13–1.60) 0.222       
Histological grade         
 Grade 1 (reference) 1   1   1   1  
 Grade 2 2.88 (1.28–6.47) 0.010 2.28 (0.99–5.24) 0.054 2.67 (1.18–6.01) 0.018 2.08 (0.89–4.83) 0.089
 Grade 3 2.92 (1.24–6.88) 0.014 1.81 (0.73–4.48) 0.198 3.08 (1.23–7.68) 0.016 2.15 (0.82–5.61) 0.119
Presence of LVI (yes vs. no) 3.81 (2.27–6.37) <.0001 3.27 (1.89–5.68) <.0001 4.21 (2.40–7.36) <.0001 3.47 (1.90–6.33) <.0001
Presence of extensive DCIS/LCIS (yes vs. no) 1.09 (0.64–1.87) 0.751    1.28 (0.72–2.26) 0.396   
  1. LVI LymphoVascular Invasion, DCIS Ductal Carcinoma In Situ, LCIS Lobular Carcinoma In Situ