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Table 3 Factors associated with sentinel node status

From: Role of patient and tumor characteristics in sentinel lymph node metastasis in patients with luminal early breast cancer: an observational study

 

Overall sample (N = 345)

Luminal subgroup (N = 297)

Univariate OR (95 % CI)

p value

Multivariate OR (95 % CI)

p value

Univariate OR (95 % CI)

p value

Multivariate OR (95 % CI)

p value

Age (increase of 10 years)

0.98 (0.79–1.22)

0.880

  

0.93 (0.74–1.18)

0.552

  

Menopausal status (pre vs. post)

1.23 (0.68–2.20)

0.495

  

1.28 (0.68–2.42)

0.450

  

Number of excised sentinel nodes (continuous variable)

1.06 (0.81–1.39)

0.656

  

1.08 (0.80–1.44)

0.627

  

Histology

        

 Ductal (reference)

1

0.127

  

1

0.205

  

 Lobular

1.02 (0.51–2.03)

   

1.06 (0.52–2.14)

   

 Mixed

1.45 (0.76–2.77)

   

1.24 (0.63–2.46)

   

 Others

0.30 (0.09–1.01)

   

0.13 (0.02–0.98)

   

 Tumor size (increase of 10 mm)

1.56 (1.14–2.13)

0.005

1.20 (0.86–1.68)

0.289

1.71 (1.19–2.45)

0.004

1.22 (0.84–1.78)

0.307

Subtype

        

 Luminal A (reference)

1

   

1

0.215

  

 Luminal B

1.39 (0.81–2.37)

0.232

  

1.41 (0.82–2.40)

   

 HER2

2.16 (0.84–5.57)

0.111

      

 Triple negative

0.46 (0.13–1.60)

0.222

      

Histological grade

        

 Grade 1 (reference)

1

 

1

 

1

 

1

 

 Grade 2

2.88 (1.28–6.47)

0.010

2.28 (0.99–5.24)

0.054

2.67 (1.18–6.01)

0.018

2.08 (0.89–4.83)

0.089

 Grade 3

2.92 (1.24–6.88)

0.014

1.81 (0.73–4.48)

0.198

3.08 (1.23–7.68)

0.016

2.15 (0.82–5.61)

0.119

Presence of LVI (yes vs. no)

3.81 (2.27–6.37)

<.0001

3.27 (1.89–5.68)

<.0001

4.21 (2.40–7.36)

<.0001

3.47 (1.90–6.33)

<.0001

Presence of extensive DCIS/LCIS (yes vs. no)

1.09 (0.64–1.87)

0.751

  

1.28 (0.72–2.26)

0.396

  
  1. LVI LymphoVascular Invasion, DCIS Ductal Carcinoma In Situ, LCIS Lobular Carcinoma In Situ