Fig. 3

The frequency of individual amino acids at specific positions (105–117) for the most prevalent H-CDR3 sequences having the length of 14 amino acids (the basic length of CDR3-IMGT) in each SLE patient is shown. The color menu for amino acids is according to IMGT (Ruiz and Lefranc 2000). H-CDR3 positions are shown according to the IMGT unique numbering. Arabic numerals (0, 1, 3) in the brackets at the bottom of the panels respectively represent three time points. a P1-0 (n = 1674), P1-1 (n = 762) and P1-3 (n = 456). b P2-0 (n = 3060), P2-1 (n = 3200) and P2-3 (n = 2423)