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Fig. 3 | SpringerPlus

Fig. 3

From: Deletion of exon 8 from the EXT1 gene causes multiple osteochondromas (MO) in a family with three affected members

Fig. 3

Localization of the mutation. Agarose gels stained with ethidium bromide are shown. a PCR amplification of the region corresponding to nucleotides 2370-2723 of the exostosin-1 mRNA (NM_000127.2) yielded two fragments of 354 and 264 bp, respectively, with samples from the mother #8 and her sons #13 and #14, but a single fragment with samples from an unrelated control as well as from father #7 and the healthy brother #12. b Long-range PCR of a fragment corresponding to the region from intron 7 to intron 8 of the EXT1 gene yielded two fragments of 5.6 and 1.4 kb, respectively, with samples from mother #8 and son #13, but a single fragment with samples from father #7 and the healthy son #12

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