Circulating growth arrest-specific protein 6 levels are associated with erythropoietin resistance in hemodialysis patients

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Table 3 A comparison of clinical variables associated with Gas6 levels

Item	Healthy control (N = 85)		Non-EPO resistance (N = 98)		EPO resistance (N = 36)
Variable	r	P value	r	P value	r	P value
Ferritin	0.022	0.845	−0.140	0.167	−0.206	0.236
SI	−0.192	0.078	−0.060	0.558	−0.148	0.395
TSAT	−0.117	0.287	−0.09	0.373	−0.154	0.378
TIBC	−0.018	0.871	0.067	0.508	0.068	0.699
i-PTH	0.043	0.694	0.139	0.171	0.056	0.748
Hematocrit	−0.248	0.022	0.141	0.164	−0.174	0.318
Albumin	−0.320	0.003	−0.096	0.343	−0.388	0.021
Phosphate	0.034	0.756	−0.116	0.254	−0.172	0.322
Calcium	−0.042	0.704	−0.003	0.977	0.043	0.805
IL-6	0.321	0.003	−0.043	0.675	0.149	0.393
hs-CRP	0.066	0.546	−0.017	0.868	0.013	0.941
Kt/V	–	–	−0.065	0.524	0.300	0.081
EPO dose	–	–	−0.118	0.244	−0.151	0.387

The correlations were estimated using the Pearson correlation test
Gas6 growth arrest-specific 6, EPO erythropoietin, SI serum iron, TSAT transferring saturation, TIBC total iron-binding capacity, i-PTH intact parathyroid hormone, Hct hematocrit, IL-6 Interleukin 6, Hs-CRP high sensitivity C-reactive protein, EPO erythropoietin