Table 1 The demographic data of patients with IV tPA treatment

N

82

148

117

119

Age (mean ± SD)

64.5 ± 11.3

68.3 ± 11.5

61.5 ± 13.2

64.9 ± 13.1

Sex (F/M)

34/48

74/74

26/91

39/80

Atrial fibrillation (%)

0 (0 %)

136 (91.9 %)

2 (1.7 %)

43 (36.1 %)

Diabetes mellitus (%)

30 (36.6 %)

36 (24.3 %)

30 (25.6 %)

35 (29.4 %)

Hypertension (%)

68 (82.9 %)

110 (74.3 %)

89 (76.1 %)

91 (76.5 %)

Hyperlipidemia (%)

46 (56.1 %)

49 (33.1 %)

62 (53.0 %)

58 (48.7 %)

Coronary artery disease (%)

3 (3.7 %)

23 (15.5 %)

13 (11.1 %)

12 (10.1 %)

Congestive heart failure (%)

1 (1.2 %)

19 (12.8 %)

2 (1.7 %)

3 (2.5 %)

Old stroke (%)

16 (19.5 %)

18 (12.2 %)

17 (14.5 %)

19 (16.0 %)

Smoking (%)

27 (32.9 %)

34 (23.0 %)

40 (34.2 %)

39 (32.8 %)

Prior antiplatelet treatment (%)

13 (15.9 %)

47 (31.8 %)

13 (11.1 %)

26 (21.8 %)

Prior anticoagulant treatment (%)

1 (1.2 %)

10 (6.8 %)

0 (0 %)

3 (2.5 %)

Systolic BP (mmHg)

156.1 ± 21.7

148.4 ± 27.8

152.0 ± 25.0

148.1 ± 21.8

Diastolic BP (mmHg)

86.6 ± 14.5

86.3 ± 18.1

85.6 ± 16.0

84.0 ± 13.7

Onset to tPA time (min)

135.7 ± 46.2

133.5 ± 71.6

135.3 ± 42.2

132.5 ± 42.0

NIHSS baseline, median (IQR)

7 (6–10)

15 (9–20)

12 (8–18)

11 (7–17)

NIHSS 2 h, median (IQR)

5 (4–8.25)

13 (7–18)

11 (7–16)

9 (5–16)

NIHSS discharge, median (IQR)

3 (1–6.25)

7 (2–15)

7 (3–13)

6 (2–11)

MRS admission, median (IQR)

4 (2–4)

4 (4–5)

4 (4–5)

4 (3–5)

MRS discharge, median (IQR)

1.5 (1–4)

4 (1–5)

4 (1.5–5)

3 (1–5)

MRS at discharge ≤1

41 (50.0 %)

40 (27.0 %)

29 (24.8 %)

36 (30.3 %)

MRS at discharge ≤2

49 (59.8 %)

43 (29.1 %)

38 (32.5 %)

45 (37.8 %)

Symptomatic ICH

1 (1.2 %)

17 (11.5 %)

5 (4.3 %)

7 (5.9 %)

Any ICH

2 (2.4 %)

50 (33.8 %)

28 (23.9 %)

19 (16.0 %)

Mortality

0 (0 %)

15 (10.1 %)

5 (4.3 %)

6 (5.0 %)