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Table 1 MICs and MBCs (µg/mL) of the nineteen tested compounds and ciprofloxacin on the panel of tested bacteria

From: Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes

Samples

Bacterial strains, MIC and MBC (µg/mL)

Escherichia coli

Enterobacter aerogenes

Klebsiella pneumoniae

Providencia stuartii

Enterobacter cloacae

Pseudomonas aeruginosa

ATCC 8739

AG102

AG100 Atet

ATCC 13048

CM64

EA27

ATCC 11296

KP55

ATCC29916

PS299645

BM47

BM67

PA01

PA124

1

256 (–)

–

–

256 (–)

–

–

–

–

–

128 (–)

–

–

–

–

2

256 (–)

–

–

256 (–)

–

–

–

–

–

256 (–)

–

–

–

–

3

8 (16)

32 (128)

32 (128)

8 (16)

32 (128)

16 (64)

4 (8)

8 (16)

8 (32)

32 (64)

4 (8)

16 (128)

32 (128)

64 (256)

4

256 (–)

256 (–)

–

256 (–)

256 (–)

256 (–)

–

–

256 (–)

256 (–)

256 (–)

–

–

–

5

–

–

–

–

–

–

–

–

–

256 (–)

–

–

–

–

6

4 (32)

8 (16)

256 (–)

256 (–)

256 (–)

16 (32)

4 (8)

8 (16)

16 (128)

64 (256)

4(8)

256 (–)

64 (256)

256 (–)

7

256 (–)

–

–

256 (–)

–

–

–

–

–

–

–

256 (–)

–

–

8

8 (32)

16 (64)

256 (–)

128 (–)

256 (–)

32 (128)

8 (16)

8 (32)

4 (16)

8 (32)

4 (16)

256 (–)

8 (32)

64 (256)

9

256 (–)

–

–

–

–

–

–

–

–

–

–

–

–

–

10

256 (–)

–

–

256 (–)

–

–

–

–

–

–

–

–

–

–

11

256 (–)

–

–

–

–

–

–

–

256 (–)

–

–

–

–

–

12

64 (128)

128 (–)

128 (–)

256 (–)

256 (–)

128 (–)

128 (256)

128 (–)

64 (256)

128 (–)

64 (128)

256 (–)

128 (256)

256 (–)

13

128 (–)

–

128 (–)

256 (–)

–

–

–

–

–

256 (–)

–

–

–

–

14

–

–

–

256 (–)

–

256 (–)

–

–

–

256 (–)

256 (–)

256 (–)

–

–

15

128 (–)

–

–

256 (–)

–

–

–

–

–

128 (–)

256 (–)

256 (–)

–

–

16

–

–

–

–

–

–

–

–

–

–

–

–

–

–

17

64 (128)

128 (–)

256 (–)

64 (256)

256 (–)

64 (256)

64 (256)

128 (–)

64 (256)

256 (–)

256 (–)

–

256 (–)

–

18

–

–

–

256 (–)

–

–

–

–

–

256 (–)

–

–

–

–

19

64 (256)

256 (–)

256 (–)

128 (–)

256 (–)

256 (–)

64 (256)

256 (–)

16 (64)

32 (256)

256 (–)

256 (–)

–

–

CHL

4 (64)

8 (–)

8 (–)

16 (128)

–

128 (–)

16 (128)

128 (–)

8 (128)

32 (–)

–

256 (–)

16 (256)

64 (256)

  1. CHL chloramphenicol, (–) MIC > 256 µg/mL, in bold significant antibacterial activity (Kuete 2010; Kuete and Efferth 2010)
  2. Atalantoflavone (1); 2′-hydroxyatalantoflavone (2); neocyclomorusin (3); 2-(3,5-dihydroxyphenyl)benzofuran-5,6-diol (4); 4-hydroxy-2,6-di-(3′,4′-dimethoxyphenyl)-3,7-dioxabicyclo-(3.3.0)octane (5); Candidone (6); isoneorautenol (7); neobavaisoflavone (8); tecleaverdoornine (9); maculine (10); deacetylnomilin (11); daidzein (12); isowighteone (13); dorstenin (14); herranone (15); 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene (17); isogarcinol (16); ulmoside A (18) and 3,4,3′-tri-O-methylellagic acid (19). Compound classes [flavonoids (1-3, 6, 18), isoflavonoids (7, 8, 12, 13), benzophenone (16), benzofuran (4), ellagic acid derrivative (19), lignan (5), alkaloids (9, 10), terpenoids (11, 15) and thiphene (19)]
  3. Bold values indicate Significant activity