Table 3 Putative functions of DDX members
From: Identification and in silico analysis of cattle DExH/D box RNA helicases
Protein | Function | Ref. |
|---|---|---|
DDX1 | Associated with ARE mediated mRNA decay | Chou et al. (2013) |
DDX3X, DDX3Y | DDX3X can bind with DNA, RNA splicing, nuclear transport of RNA and translational regulation | |
DDX4 | Bovine vasa homolog (BVH) and is expressed in gonads | Bartholomew and Parks (2007) |
DDX5, DDX17 | Splicing and transcriptional regulation | Auboeuf et al. (2002) |
DDX6 | Spermatogenesis and localized in spermatogenic cells | Kawahara et al. (2014) |
DDX10 | Ribosome assembly | Savitsky et al. (1996) |
DDX18 | Hematopoiesis and deletion resulted into p-53 depended cell arrest in G1 | Payne et al. (2011) |
DDX19 | m-RNA nuclear transport by remodelling of RNP particles through nuclear pore complex | Collins et al. (2009) |
DDX20 | Transcriptional regulation, splicing process and mi-RNA pathway | Takata et al. (2012) |
DDX23 | Pre-mRNA splicing | Ismaïli et al. (2001) |
DDX24 | Innate immune signalling regulation | Ma et al. (2013) |
DDX25 | Posttranscriptional regulations of genes for spermatid elongation & completion of spermatogenesis | Dufau and Tsai-Morris (2007) |
DDX27 | ND | Â |
DDX28 | Cellular division | Loo et al. (2012) |
DDX31 | Transcription of rRNA gene and assembly of 60Â s ribosomal subunit | Bish and Vogel (2014) |
DDX39 | mRNA splicing, genome integrity and telomere protection | Yoo and Chung (2011) |
DDX41 | Type 1 interferon response | Zhang et al. (2011a) |
DDX42 | Function as chaperon | Uhlmann-Schiffler et al. (2006) |
DDX43 | ND | Â |
DDX46 | Pre-mRNA splicing | Hozumi et al. (2012) |
DDX47 | Pre-RNA processing | Sekiguchi et al. (2006) |
DDX49 | ND | Â |
DDX51 | Ribosome synthesis and formation of 3′end of 28S rRNA | Srivastava et al. (2010) |
DDX52 | ND | Â |
DDX53 | ND | Â |
DDX54 | Maintenance of central nervous system | Zhan et al. (2013) |
DDX55 | ND | Â |
DDX56 | Assembly of pre-ribosomal particles | Zirwes et al. (2000) |
DDX59 | Pathogenesis of orofaciodigital syndrome | Shamseldin et al. (2013) |
EIF4A | eIF4F complex formation and facilitates translation | Harms et al. (2014) |
Nucleolar RNA Hel2 (DDX21) | RNA processing during interphase of mitosis | De Wever et al. (2012) |