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Table 2 Median (range) changes in SLE-characteristics during etomidate administration

From: The general anesthetic propofol induces ictal-like seizure activity in hippocampal mouse brain slices

Location

Baseline

Last dose

End period

P value

Entorhinal cortex

 Amplitude (µV)

79.9 (28.3–229.8)

95.7 (20.8–172.9)

108.0 (30.0–199.3)

ns

 Frequency (/min)

2.7 (0.4–4.0)

1.2 (0.2–1.9)a

2.7 (0.5–6.5)b

0.0004*

 Length (s)

2.9 (2.1–143.3)

2.5 (1.0–246.6)

3.4 (1.3–73.7)

ns

Neocortex

 Amplitude (µV)

136.6 (46.8–502.6)

178.5 (75.0–663)c

141.2 (67.4–633.0)

0.0084**

 Frequency (/min)

3.4 (3.2–5.2)

1.3 (0.3–3.4)

3.7 (0.7–12.7)

0.0515**

 Length (s)

2.2 (1.2–3.4)

1.5 (1.1–1.7)

1.7 (1.5–3.6)

ns

Hippocampus

 Amplitude (µV)

90.1 (11.8–280.5)

103.8 (11.9–428.6)

135.1 (14.3–346.6)d

0.0398*

 Frequency (/min)

5.8 (3.5–7.9)

2.1 (0.1–5.1)c

4.5 (2.3–17.6)

0.0013**

 Length (s)

1.1 (1.0–3.2)

1.2 (0.9–1.7)

1.2 (1.0–3.2)

ns

  1. * p values generated from repeated measures analysis of variance (ANOVA)
  2. ** p values generated from Freidman test (nonparametric repeated measures ANOVA)
  3. ap < 0.01 compared to baseline, Tukey–Kramer multiple comparisons test
  4. bp < 0.001 compared to last dose, Tukey–Kramer multiple comparisons test
  5. cp < 0.01 compared to baseline, Dunn’s multiple comparisons test
  6. dp < 0.05 compared to baseline, Dunn’s multiple comparisons test
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