The general anesthetic propofol induces ictal-like seizure activity in hippocampal mouse brain slices

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Table 1 Median (range) changes in SLE-characteristics during propofol administration

Location	Baseline	Last dose	End period	P value
Entorhinal cortex
Amplitude (µV)	92.5 (23.7–341.9)	111.3 (25.9–310)	96 (36.6–429)	ns
Frequency (/min)	2.0 (1.3–4.9)	0.7 (0.3–1.1)^a	0.7 (0.3–1.4)^a	<0.0001*
Length (s)	3.6 (1.1–9.9)	9.1 (1.0–51.5)	18.9 (1.1–49)^b	0.0155*
Neocortex
Amplitude (µV)	138.7 (37–494)	245.7 (34.3–615)^c	229.4 (38.8–429.2)	0.0302*
Frequency (/min)	2.5 (0.6–4.4)	0.6 (0.0–3.6)^d	0.7 (0.1–4.5)^d	<0.0001**
Length (s)	2.3 (1–5.1)	1.9 (0–12.6)	1.8 (1–6.5)	ns

* p values generated from repeated measures analysis of variance (ANOVA)
** p values generated from Freidman test (nonparametric repeated measures ANOVA)
^ap < 0.001 compared to baseline, Tukey–Kramer multiple comparison test
^bp < 0.05 compared to baseline, Tukey–Kramer multiple comparisons test
^cp < 0.05 compared to baseline, Dunn’s multiple comparisons test
^dp < 0.001 compared to baseline, Dunn’s multiple comparisons test