Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival

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Table 3 Univariate and multivariate analyses of factors predisposing to disease-specific survival in only cases with stage III and IV cancer

Variable	Univariate analysis			Multivariate analysis
Variable	Hazard ratio	95 % CI	P value	Hazard ratio	95 % CI	P value
Age ≥ 70 years	3.163	1.038–9.130	0.043	4.243	0.999–17.759	0.050
Sex (male)	1.247	0.432–3.796	0.682	2.515	0.679–10.827	0.168
Poor differentiation	3.891	0.861–13.096	0.073	1.843	0.284–10.948	0.504
Patients treated without surgery	3.710	1.251–11.643	0.018	2.376	0.628–9.456	0.199
High budding grade	4.930	1.449–15.574	0.012	11.914	1.772–96.778	0.010
High Ln5-γ2 expression level	2.829	0.915–8.332	0.069	0.797	0.114–4.486	0.805