Table 1 Clinicopathological features of 46 patients with SCC of EAC and their correlation to tumor growth pattern and budding grade
All | Tumor budding | Budding grade | |||||
|---|---|---|---|---|---|---|---|
n (%) | Absent 13 (28.3) | Present 33 (71.7) | P value | Low 39 (84.8) | High 7 (15.2) | P value | |
Mean age [years, (sd)] | 62.5 (±11.4) | 65.0 (±3.1) | 61.5 (±1.9) | 0.358 | 63.1 (±1.8) | 59.3 (±0.4.3) | 0.426 |
M:F | 21:25 (46:54) | 8:5 (62:38) | 17:16 (52:48) | 0.743 | 21:18 (54:46) | 4:3 (57:43) | 1.000 |
T | |||||||
T1 | 1 (2.2) | ||||||
T2 | 12 (26.1) | 4 (30.8) | 9 (27.3) | 11 (28.2) | 2 (28.6) | ||
T3 | 9 (19.5) | ||||||
T4 | 24 (52.2) | 9 (69.2) | 24 (72.7) | 1.000 | 28 (84.8) | 5 (71.4) | 1.000 |
N | |||||||
N0 | 36 (78.3) | 11 (84.6) | 25 (75.8) | 31 (79.5) | 5 (71.4) | ||
N+ | 10 (21.7) | 2 (15.4) | 8 (24.2) | 0.700 | 8 (20.5) | 2 (28.6) | 0.636 |
M | |||||||
M0 | 44 (95.7) | 13 (100) | 31 (94.0) | 38 (97.4) | 6 (85.7) | ||
M+ | 2 (4.3) | 0 (0) | 2 (6.0) | 1.000 | 1 (2.6) | 1 (14.3) | 0.284 |
TNM stage | |||||||
Stage I | 1 (2.2) | ||||||
Stage II | 10 (21.7) | 4 (30.8) | 7 (21.2) | 10 (25.6) | 1 (14.3) | ||
Stage III | 10 (21.7) | ||||||
Stage IV | 25 (54.4) | 9 (69.2) | 26 (78.8) | 0.702 | 29 (74.4) | 6 (85.7) | 1.000 |
Differentiation | |||||||
Well | 28 (60.9) | 7 (53.8) | 21 (63.6) | 26 (66.7) | 2 (28.6) | ||
Moderate | 15 (32.6) | 6 (46.2) | 9 (27.3) | 11 (28.2) | 4 (57.1) | ||
Poor | 3 (6.5) | 0 (0) | 3 (9.1) | 0.309 | 2 (5.1) | 1 (14.3) | 0.157 |
Recurrence | 21 | ||||||
Free | 15 (71.4) | 4 (80.0) | 11 (68.8) | 15 (78.9) | 0 (0) | ||
Recurrence | 6 (28.6) | 1 (20.0) | 5 (31.2) | 1.000 | 4 (21.1) | 2 (100) | 0.071 |
Effect of therapy | 18 | ||||||
Grade 0–2 | 11 (61.1) | 1 (25.0) | 10 (71.4) | 9 (60.0) | 2 (66.7) | ||
Grade 3 | 7 (38.9) | 3 (75.0) | 4 (28.6) | 0.245 | 6 (40.0) | 1 (33.3) | 1.000 |