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Fig. 1 | SpringerPlus

Fig. 1

From: Structural homology guided alignment of cysteine rich proteins

Fig. 1

Overview of barcode alignment method. Lack of sequence conservation and abundance of cysteines prevents automatic alignment by standard methods. Homologous cysteines identified from structural alignment are replaced with 10aa barcodes to pin them in place. Standard algorithms are used to realign free loops between the barcoded columns. Barcodes are exchanged for the original columns for the final alignment and phylogeny calculation. Sequences are coloured with cysteines in yellow, any other residue in grey, gaps in light grey, and barcode sequences in blue

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