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Table 3 Pharmacokinetic parameters of Cipterbin® after single dose administration

From: A phase I dose-escalation study of a biosimilar trastuzumab in Chinese metastasis breast cancer patients

Parameter Unit 100 mg (n = 9) 250 mg (n = 9) 500 mg (n = 9)
AUC0–672 µg h/mL 4304 ± 1220 7368 ± 2142 22,386 ± 6774
AUC0–∞ µg h/mL 4510 ± 1214 7615 ± 2203 23,349 ± 7615
t1/2 h 81 ± 13 112 ± 20 144 ± 25
CL mL kg/d 8.6 ± 1.7 13.5 ± 4.4 9.0 ± 2.8
Vd mL/kg 38.1 ± 6.2 74.0 ± 18.4 63.3 ± 18.9
Cmax µg/mL 38.1 ± 7.4 72.5 ± 12.8 173.9 ± 23.8
  1. Data are shown as mean ± SD