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Table 3 Pharmacokinetic parameters of Cipterbin® after single dose administration

From: A phase I dose-escalation study of a biosimilar trastuzumab in Chinese metastasis breast cancer patients

Parameter

Unit

100 mg (n = 9)

250 mg (n = 9)

500 mg (n = 9)

AUC0–672

µg h/mL

4304 ± 1220

7368 ± 2142

22,386 ± 6774

AUC0–∞

µg h/mL

4510 ± 1214

7615 ± 2203

23,349 ± 7615

t1/2

h

81 ± 13

112 ± 20

144 ± 25

CL

mL kg/d

8.6 ± 1.7

13.5 ± 4.4

9.0 ± 2.8

Vd

mL/kg

38.1 ± 6.2

74.0 ± 18.4

63.3 ± 18.9

Cmax

µg/mL

38.1 ± 7.4

72.5 ± 12.8

173.9 ± 23.8

  1. Data are shown as mean ± SD
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