Table 2 Number of patients with drug-related adverse events
Total (n = 27) | 100 mg (n = 9) | 250 mg (n = 9) | 500 mg (n = 9) | |||||
|---|---|---|---|---|---|---|---|---|
Rang 1.35–1.89 mg/kg | Rang 3.65–6.25 mg/kg | Rang 6.41–11.11 mg/kg | ||||||
Grade 1/2 No. (%) | Grade 3/4 No. (%) | Grade 1/2 No. (%) | Grade 3/4 No. (%) | Grade 1/2 No. (%) | Grade 3/4 No. (%) | Grade 1/2 No. (%) | Grade 3/4 No. (%) | |
Fever | 16 (59.3) | 0 | 5 (55.6) | 0 | 3 (33.3) | 0 | 8 (88.9) | 0 |
Transit increased ALT/AST | 6 (22.2) | 0 | 1 (11.1) | 0 | 3 (33.3) | 0 | 2 (22.2) | 0 |
Chills | 5 (18.5) | 0 | 2 (22.2) | 0 | 2 (22.2) | 0 | 1 (11.1) | 0 |
Arrhythmia | 5 (18.5) | 1 (3.7) | 2 (22.2) | 0 | 2 (22.2) | 1 (11.1) | 0 | 0 |
Fatigue | 4 (14.8) | 0 | 1 (11.1) | 0 | 2 (22.2) | 0 | 1 (11.1) | 0 |
Dyspnea | 4 (14.8) | 0 | 1 (11.1) | 0 | 3 (33.3) | 0 | 0 | 0 |
Arthralgia | 4 (14.8) | 0 | 2 (22.2) | 0 | 2 (22.2) | 0 | 0 | 0 |
Nausea/vomiting | 3 (11.1) | 0 | 1 (11.1) | 0 | 2 (22.2) | 0 | 0 | 0 |
Palpitation | 3 (11.1) | 0 | 1 (11.1) | 0 | 2 (22.2) | 0 | 0 | 0 |
Headache | 2 (7.4) | 0 | 2 (22.2) | 0 | 0 | 0 | 0 | 0 |
Dry mouth | 2 (7.4) | 0 | 1 (11.1) | 0 | 0 | 0 | 1 (11.1) | 0 |
Rash | 2 (7.4) | 0 | 1 (11.1) | 0 | 1 (11.1) | 0 | 0 | 0 |