Skip to main content

Table 1 Demographics and characteristics of treated patients

From: A phase II study of afatinib, an irreversible ErbB family blocker, added to letrozole in patients with estrogen receptor-positive hormone-refractory metastatic breast cancer progressing on letrozole

 

N (%)a

Total number

28 (100)

Sex

 Female

28 (100)

Age (years)

 Mean

62.5

 Median

64

 Range

40–82

Baseline ECOG performance status

 0

16 (57)

 1

8 (29)

 2b

4 (14)

Progesterone receptor positive

20 (71)

Estrogen receptor positive

27 (96)

HER2 status

 HER2 positive

3 (11)

 HER2 negative

20 (71)

 HER2 unknown or missing

5 (18)

Prior therapies

 

 Chemotherapy

24 (86)

Prior adjuvant or neoadjuvant chemotherapy

 

 Yes

19 (68)

 No

9 (32)

Number of prior metastatic chemotherapies

 

 0

18 (64)

 1

9 (32)

 ≥2

1 (4)

Hormone therapy prior to letrozole

28 (100)

Prior adjuvant radiotherapy

 

 Yes

16 (57)

 No

12 (43)

Number of prior metastatic radiotherapies

 

 0

16 (57)

 1

7 (25)

 ≥2

7 (18)

  1. ECOG Eastern Cooperative Oncology Group, HER2 human epidermal growth factor receptor 2
  2. aUnless otherwise specified
  3. bAt screening, the ECOG PS for these patients was 0–1; however, their scores worsened to 2 prior to the start of treatment