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Table 2 The effect of MEKK1 suppression on metastatic capacity of 4T1 cells

From: MAP3K1-targeting therapeutic artificial miRNA suppresses the growth and invasion of breast cancer in vivo and in vitro

Group

Death rate

Incidence of metastasis

Nodules/lung

Ctrl amiRNA

4/10

10/10

17 ± 9

Map3k1 amiRNA-3

2/10

8/10

8 ± 5*

  1. Data showed that control-amiRNA 4T1 cells formed significantly higher numbers of tumor niches than Map3k1 amiRNA-overexpressing ones (*p < 0.05)