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Fig. 6 | SpringerPlus

Fig. 6

From: MAP3K1-targeting therapeutic artificial miRNA suppresses the growth and invasion of breast cancer in vivo and in vitro

Fig. 6

Overexpression of Map3k1 amiRNA attenuated the in vivo tumor formation of 4T1 breast cancer cells. A Representative images of tumor formation in control-amiRNA and Map3k1 amiRNA-overexpressing cells in nude mice. B The growth curve of control-amiRNA and Map3k1 amiRNA-overexpressing tumors (*p < 0.05). C HE staining of control-amiRNA and Map3k1 amiRNA-overexpressing tumors indicated that control tumors displayed necrotic-like structure, invasion into muscle and fat tissues, whereas similar phenomena were not identified in Map3k1 amiRNA-overexpressing tumors (a, arrowheads indicated necrotic-like region; b, arrowhead indicated tumor invasion into muscle tissues; c, arrowhead tumor invasion into fat tissues)

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