Fig. 1

Representative thrombin generation curves from an individual blood donor measured in PRP, after whole blood incubation for 1 h à at 37 °C with: a Enox (blood concentration 0.5–2.0 IU/m/L), and b Enox/Eth (blood concentration 0.5–2.0 IU/m/L) Thrombogram parameters—Lag-time (min): initiation phase of thrombin generation; Peak: maximal concentration (Cmax) of thrombin generated, expressed in nM; Time to peak (TtPeak time in min) necessary to achieve maximal thrombin concentration (Tmax); Endogenous thrombin potential (ETP): (nMxmin) area under the curve (represents thrombin molecule activity in plasma); Start-Tail: time (min) to at the term of which the curve of the thrombogram returns to zero