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Table 2 Level-by-level diagnostic performance of three methods (CT, PET/CT with best SUVmax cut-off, and PET/CT with level-based modified SUVmax cut-off)

From: Clinical significance of SUVmax in 18F-FDG PET/CT scan for detecting nodal metastases in patients with oral squamous cell carcinoma

  TP FN TN FP Sensitivity Specificity PPV NPV Accuracy
95 % CI 95 % CI 95 % CI 95 % CI 95 % CI
CT 12 16 215 7 42.9a,b 96.8 63.2 93.1 90.8c
     24.6–61.2 94.5–99.1 41.5–84.9 89.8–96.4 87.2–94.4
FDG-PET/CT using best SUVmax cut-off (3.5) 19 9 210 12 67.9a 94.6 61.3 95.9 91.6
     50.6–85.2 91.6–97.6 59.8–62.8 93.3–98.5 88.2–95.0
FDG-PET/CT usinglevel-based modified SUVmax cut-off 20 8 213 9 71.4b 95.9 69 96.4 93.2c
     54.7–88.1 93.3–98.5 67.6–70.5 93.9–98.9 90.1–96.3
  1. TP true positive, FN false negative, TN true negative, FP false positive, PPV positive predictive value, NPV negative predictive value, CI confidence interval
  2. aThe sensitivity of FDG-PET/CT with best SUVmax cut-off (3.5) was significantly higher than that of CT (p = 0.023)
  3. bThe sensitivity of FDG-PET/CT with level-based modified SUVmax cut-off was significantly higher than that of CT (p = 0.013)
  4. cThe accuracy of FDG-PET/CT with level-based modified SUVmax cut-off was significantly higher than that of CT (p = 0.041)