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Table 3 Screening of solvents for hexanoylation of diol 5 mediated by lipase TL^a

From: Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)

Entry	Conditions	Conversion (%)^b	Ee of 7 (%)^c
1	iPr₂O, rt → 50 °C, 19 h	30	6.4
2	Benzene, rt, 48 h	70	65
3	CH₂Cl₂, rt → 35 °C, 54 h	34	70

^aTwo equiv of vinyl hexanoate, and a same amount of lipase, as diol 5, were used
^bDetermined by ¹H NMR
^cDetermined by chiral HPLC analysis

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