Skip to main content
SpringerPlus

Table 1 Screening of lipases for enantioselective acetylation of diol 5 a

From: Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG)

Entry

Lipase

Time (h)

Conversion (%)b

Ee of 6 (%)c

1

AK

21

N.R.

–

2

PS-IM

48

N.R.

–

3

XP-488

72

N.R.

–

4

OF

24

N.R.

–

5

QLM

72

59

47

6

PL

24

29

41

7

Novozyme 435

24

42

9.5

8

TL

72

33

76

  1. N.R. no reaction
  2. aTwo equiv of vinyl acetate, and a same amount of lipase, as diol 5, were used
  3. bDetermined by 1H NMR
  4. cDetermined by chiral HPLC analysis
Back to article page