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Table 2 Different published studies used radiotherapy for PPTID

From: Are we over treating Pineal Parenchymal tumour with intermediate differentiation? Assessing the role of localised radiation therapy and literature review

Authors

Total Number of patients in the study

Total number of patients with radiotherapy

Number of patients with Craniospinal radiotherapy

Dose

Stereotactic

Chemotherapy

Outcome

Schild et al. (1993)

4

4

Not clear

45–64.8 Gy

Not clear

Not clear

No specific data

Fauchon et al. (2000)

26 patients were classified as Grade 2 and Grade 3 not PPID

14

12

Neuroaxis

Dose average 31 Gy (range 10–38 Gy)

Yes

Yes 6 patients

Various regime

5 years survival 74 % and 39 % for Grade 2 and 3 respectively

Lutterbach et al. (2002)

37 specimens were retrospectively analysed to classify them as PPTIDs

Not clear

Not clear

Range 20–75 Gy

Median 54 Gy

Yes

Yes

Cis/Vin, Cis/Eto, Cap/Ifo,

VIP16/Cis, Vip16/D/F, MTX it, LO/CIS/VI

Median overall survival 165 months

Stoiber et al. (2010)

1

1

0

54 Gy/30 f L

No

No

Time to progression 84 months

Tsubasa et al. (2014)

5

5

2

L 54 Gy,

CSI 36 Gy

WVI 18

No

Yes 4 patients

VNCI

Medial overall survival 94.1 months

Ito et al. (2014)

6

6

4

22 Gy/10 f L

54.4 Gy/28 f WB + L+WS

50 Gy/25 f

EL+L

Yes

Yes 3 patients

ACNU,VDS,VCR,ICE

Median event free survival 39 months

  1. L local, EL extended local, WB whole brain, WS whole spine, WVI whole ventricular irradiation, VNCI vincristine, nimustine, carboplatin, interferon, CSI craniospinal irradiation, ACNU, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride, VDS vindesine, VCR vincristine; ICE ifosfamide + cis-platinum + etoposide, Cis cisplatinum, Vi vincristine, VP16 etoposide, MTX methotrexate, l0 Lomustiene