Fig. 4

Effect of mutolide on a TNF-α induced NF-κB activation in CEM-κB cells transfected with the κB element, b translocation of phospho NF-κB and c phosphorylation of IκBα. TNF-α induced CEM-κB cells were treated with mutolide and the effect on NF-κB expression at the end of 16 h was determined. Mutolide showed inhibition of TNF-α induce NF-κB activation and the translocation of phospho NF-κB, but not the phosphorylation of IκBα