Table 4 The main pharmacokinetic parameters for hetrobopag after intragastric administration of 10, 30 and 60 mg/kg to rat, respectively (mean ± SD, n = 6)
Parameters | 10 mg/kg | 30 mg/kg | 60 mg/kg |
|---|---|---|---|
Cmax (µg/mL) | 13.1 ± 6 | 21.6 ± 12.3 | 34.6 ± 11.9 |
Tmax (h) | 0.7 ± 0.26 | 1.67 ± 0.52 | 2.58 ± 2.06 |
AUC0–48 h (µg h/mL) | 46.2 ± 31 | 127.7 ± 70.8 | 306.6 ± 94.6 |
AUC0–∞ (µg h/mL) | 46.7 ± 31.3 | 129.8 ± 72.8 | 312.8 ± 98.8 |
MRT (h) | 6.5 ± 0.7 | 8.4 ± 1.7 | 105 ± 1.3 |
t1/2 (h) | 8.5 ± 1.1 | 8.4 ± 1.1 | 8.8 ± 1.1 |