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Table 3 Stability of hetrombopag in rat plasma under various storage conditions (n = 3)

From: Development and validation of a LC–MS/MS method for quantification of hetrombopag for pharmacokinetics study

Storage conditions

Concentration (ng/mL)

RSD (%)

RE (%)

Nominal

Calculated

Long-term (−80 ℃ 45 days)

2

2.02

4.5

1.2

800

700

2.6

−12.5

Short-term (room temperature 4 h)

2

2.12

5.2

5.8

800

713

2.9

−10.9

Three freeze/thaw cycles (−80 ℃)

2

2.17

6

8.5

800

710

5.3

−11.3

Post-preparative (room temperature 24 h)

2

2.18

5.8

9.2

800

726

6

−9.2