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Table 1 Demographic and clinical characteristics of renal transplant recipients treated by TAC and SRL

From: CYP3A5 and ABCB1 genotype influence tacrolimus and sirolimus pharmacokinetics in renal transplant recipients

 

TAC

SRL

Number (N)

112

43

Age (years)

35 (31–46)

35 (34–46)

Sex (male/female)

70/42

30/13

Therapy time (month)

11 (7–20)*

6 (4–10)

Concentration (ng/mL)

4.5 (3.9–5.8)

5.9 (3.5–8.3)

Glucose (mmol/L)

4.81 (4.6–5.2)

5.09 (4.86–5.77)

Systolic pressure (mmHg)

132 (126–140)

126 (110–138)

Diastolic pressure (mmHg)

98 (67–117)

87 (65–106)

ALT (IU/L)

18.6 (14.2–25.8)*

26 (18–37.5)

AST (IU/L)

23 (16.3–26)*

25.5 (20.5–36.2)

Cholesterol (mg/dL)

4.67 (3.97–5.51)*

5.4 (4.92–5.77)

Triglyceride (mg/dL)

1.23 (0.98–2.14)

1.68 (1.09–2.21)

Creatinine (mg/dL)

1.4 (1.08–2.14)*

1.20 (1.06–1.76)

Proteinuria (g/mL)

0.2 (0.1–0.5)

0.3 (0.2–0.7)

Imunosuppressive

TAC/MMF/

SRL/MMF/

Regimen

Prednisolone

Prednisolone

  1. The datas were expressed as median (range)
  2. * P < 0.05 compared with SRL group