Table 3 Genes whose expression pretreatment is associated with clinical response to chemotherapy as measured by calipers
Gene | Fold change CR/(PR + SD + PD) | Fold change CR/PR | Role and references | Chromosomal location |
|---|---|---|---|---|
Schedule A | ||||
PGM2 | N.S. | −2.0 | Phosphoglucomutase-2; deletion mutation in cervical cancer (Marshall et al. 1979) | 4p14 |
GSDMB | +4.0 | +3.8 | Gasdermin B; overexpressed in gastric and esophageal cancers; expressed in proliferating cells, but not differentiated cells; site of recombination hotspot around ERBB2 (Katoh 2004; Saeki et al. 2009) | 17q12 |
ERBB2 | +5.6 | +5.2 | ERBB2; Highly correlated to clinical response in breast cancer (Coon et al. 2002; Pritchard et al. 2006) | 17q12 |
FAM114A1 | −2.0 | −2.0 | Also called NOXP20; protein overexpressed in the nervous system (Boucquey et al. 2006) | 4p14 |
PNMT | +13.25 | Phenylethanolamine N-methyltransferase; associated with ERBB2 amplification, catalyzes synthesis of epinephrine to norepinephrine (Staaf et al. 2010) | 17q12 | |
BTN2A2 | +2.2 | Butyrophilin; Inhibits AKT pathway; expression in epithelial and ovarian cancer associated with higher infiltrating T cells; associated with better prognosis (Ammann et al. 2013) | 6p22 | |
TCAP | +3.7 | Titin-Cap protein; associated with the ERBB2 amplicon in breast cancer; associated with ERBB2 genetic polymorphisms associated with gastric cancer; associated with growth factor myostatin (Benusiglio et al. 2006; Nicholas et al. 2002; Qiu et al. 2014) | 17q12 | |
ONECUT2 | +4.9 | Tumor suppressor gene repressed in lung cancer; promotes growth of liver cells (Rauch et al. 2006) | 18q21 | |
Gene | Fold change CR/(PR + SD + PD) | Fold change CR/PR | Fold change PR/SD | Role and references | Chromosomal location |
|---|---|---|---|---|---|
Schedule B | |||||
PSTK | +2.7 | Phosphoseryl tRNA Sec Kinase; involved in selenocysteine biosynthesis; important for ribosomal protein synthesis (Yuan et al. 2006) | 10q | ||
ANXA6 | −1.8 | Annexin A6; activates NF-ĸB survival pathway, contributes to invasiveness in breast cancer cells; correlates with poor survival/mets in lung cancer (Biaoxue et al. 2012; Campbell et al. 2013; Sakwe et al. 2011) | 5q32 | ||
LINGO1 | −3.1 | LINGO 1 protein; promotes apoptosis (Zhang et al. 2013) | 15q24 | ||
SEMA4D | +33 | Semaphorin 4A; binds to Plexin B1, which physically associates with and activates ERBB2 (Cagnoni and Tamagnone 2014; Malik et al. 2014) | 1q22 | ||