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Table 3 The comparison of sensitivity and specificity of threshold values of diagnostic tools for prediabetes, DM and glucose intolerance diagnosis

From: Rational diagnoses of diabetes: the comparison of 1,5-anhydroglucitol with other glycemic markers

 

Diagnostic tool

Optimal threshold valuea

Sensitivity

Specificity

Prediabetesb

FPG (mg/dl)

96.50

0.721

0.868

Glycated hemoglobin (%)

5.60

0.706

0.816

Fructosamine (µmol/l)

230.50

0.676

0.579

1,5-AG (nmol/ml)

38.79

0.618

0.711

HOMA-IR

3.00

0.618

0.684

DM

FPG (mg/dl)

112.50

0.727

0.953

Glycated hemoglobin (%)

5.99

0.864

0.726

Fructosamine (µmol/l)

249.50

0.727

0.755

1,5-AG (nmol/ml)

30.97

0.591

0.443

HOMA-IR

3.21

0.818

0.585

Glucose intolerance

FPG (mg/dl)

97.50

0.744

0.947

Glycated hemoglobin (%)

5.60

0.767

0.816

Fructosamine (µmol/l)

233.50

0.656

0.632

1,5-AG (nmol/ml)

33.22

0.633

0.658

HOMA-IR

3.00

0.678

0.684

  1. Total study population (128 patients) was analyzed for the evaluation of the markers as a diagnostic tool for DM and glucose intolerance
  2. aThreshold value for each diagnostic tool calculated as the nearest point of ROC curve that sensitivity 100 %, false positivity is 0 %
  3. bDM patients were excluded (106 patients were analyzed) for the evaluation of the markers as a diagnostic tool for Prediabetes