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Table 2 Morphometric measure at sacrifice

From: Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation

 

Early

Late

Sham (n = 8)

AR + SIL (n = 8)

AR (n = 7)

p value (disease)

p value (treatment)

AR + SIL (n = 6)

AR (n = 5)

p value (treatment)

Body weight, g

670 ± 18

627 ± 13

711 ± 28

0.23

0.01*

657 ± 28

731 ± 53

0.23

Heart weight, g

1.66 ± 0.07

2.07 ± 0.13

2.45 ± 0.16

<0.05*

0.08

2.00 ± 0.11

2.27 ± 0.25

0.30

Heart weight ratio*, mg

2.49 ± 0.12

3.30 ± 0.17

3.47 ± 0.23

<0.01*

0.57

3.06 ± 0.21

3.08 ± 0.18

0.94

LV weight, g

1.24 ± 0.08

1.51 ± 0.09

1.76 ± 0.13

0.01*

0.13

1.49 ± 0.09

1.65 ± 0.17

0.40

RV weight, g

0.26 ± 0.01

0.30 ± 0.02

0.36 ± 0.03

<0.05*

0.14

0.31 ± 0.03

0.36 ± 0.04

0.34

Lung weight, g

1.59 ± 0.03

1.73 ± 0.04

2.10 ± 0.36

0.11

0.34

1.69 ± 0.07

1.72 ± 0.11

0.86

  1. Comparison of morphometric measures at sacrifice between sham and AR (disease p value) and between AR and AR+SIL (treatment p value). Left ventricle (LV) and right ventricle (RV)
  2. * p value < 0.05
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