Fig. 4

Serum of MBL-deficient patients (P1–P4) compared with IgG-deficient patients (normal MBL activity, C1–C6) and normal human serum (NHS pooled from healthy controls). All sera exhibited significant killing activity against Cani and Cyno, except patient P1 (arrow), which in addition to MBL-deficiency, had a reduced activity in the classical pathway. Inoculum was 1 × 10⁶ CFU/ml, the lowest level of detection was 1000 CFU/ml, the serum concentration was 50 % and the time of incubation was 90 min