An efficient and safe process for the preparation of ticagrelor, a platelet aggregation inhibitor via resin-NO2 catalyzed formation of triazole ring

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Table 3 Monitoring the elimination of impurities in downstream process for 1

Sample station (for HPLC analysis)	Impurities and there content by HPLC (%)
Sample station (for HPLC analysis)	1	12	16	26	27	SMUI
Crude	99.25	ND	ND	0.32	0.01	0.06
Acetonitrile purification	99.74	ND	ND	0.05	0.01	0.06
Crude	98.70	0.07	ND	0.30	0.06	0.14
Acetonitrile purification	99.60	ND	ND	0.05	0.01	0.05
Crude	99.44	ND	ND	0.29	0.02	0.03
Acetonitrile purification	99.78	ND	ND	0.04	ND	0.03