Table 1 Abbreviations and concentrations of chemicals used in this study
From: Assessing developmental toxicity of caffeine and sweeteners in medaka (Oryzias latipes)
Chemical | CAS number | Log P | LD50 (oral) | Molecular weight | Abbreviation | Concentration | N | ||
|---|---|---|---|---|---|---|---|---|---|
Behavior | Embryonic development | mM | mg/ml | ||||||
Sucrose | 57-50-1 | −3.70a | 29,700 mg/kg [Rat]a | 342.3 | SUC | SUC1 | 29 | 10 | 15 |
SUC2 | 146 | 50 | 14 | ||||||
Aspartame | 22839-47-0 | −0.10b | >10,000 mg/kg [Rat]c | 294.3 | ASP | ASP1 | 0.2 | 0.06 | 15 |
ASP2 | 1.0 | 0.30 | 15 | ||||||
Saccharin | 81-07-2 | 0.91a | 17,000 mg/kg [Mouse]a | 183.2 | SAC | SAC1 | 0.005 | 0.001 | 14 |
SAC2 | 0.050 | 0.010 | 14 | ||||||
Caffeine | 58-08-2 | −0.07a | 127 mg/kg [Mouse]a | 194.2 | CAF | CAF1 | 0.05 | 0.01 | 14 |
CAF2 | 0.50 | 0.10 | 14 | ||||||
– | – | – | – | – | CAF + SUC | CAF2 + SUC1 | Refer to individual compounds | 11 | |
– | – | – | – | – | CAF + ASP | CAF2 + ASP1 | 11 | ||
– | – | – | – | – | CAF + SAC | CAF2 + SAC1 | 11 | ||
Control | – | – | – | – | – | – | – | 38 | |