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Table 1 Abbreviations and concentrations of chemicals used in this study

From: Assessing developmental toxicity of caffeine and sweeteners in medaka (Oryzias latipes)

Chemical CAS number Log P LD50 (oral) Molecular weight Abbreviation Concentration N
Behavior Embryonic development mM mg/ml
Sucrose 57-50-1 −3.70a 29,700 mg/kg [Rat]a 342.3 SUC SUC1 29 10 15
SUC2 146 50 14
Aspartame 22839-47-0 −0.10b >10,000 mg/kg [Rat]c 294.3 ASP ASP1 0.2 0.06 15
ASP2 1.0 0.30 15
Saccharin 81-07-2 0.91a 17,000 mg/kg [Mouse]a 183.2 SAC SAC1 0.005 0.001 14
SAC2 0.050 0.010 14
Caffeine 58-08-2 −0.07a 127 mg/kg [Mouse]a 194.2 CAF CAF1 0.05 0.01 14
CAF2 0.50 0.10 14
CAF + SUC CAF2 + SUC1 Refer to individual compounds 11
CAF + ASP CAF2 + ASP1 11
CAF + SAC CAF2 + SAC1 11
Control 38
  1. – not applicable
  2. aThe Human Metabolome Database, http://www.hmdb.ca/
  3. bThe DrugBank Database, http://www.drugbank.ca/
  4. cTCI America Material Safety Data Sheet, https://www.spectrumchemical.com/MSDS/TCI-A0997.pdf