Fig. 2

Effects of sucrose (SUC), aspartame (ASP), saccharin (SAC), caffeine (CAF), and CAF combined with each sweetener on medaka development at 3 days post fertilization or at hatch. Data were percents of control values and expressed as mean ± SEM. *Significantly different from the control or between pairs of groups, p < 0.05; **p < 0.01; ***p < 0.001. The abbreviations and concentrations of the substances are listed in Table 1