Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation

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Table 1 Animal characteristics and echocardiography data at the end of the protocol

Parameters	Sham (n = 10)	Sham Rapa (n = 9)	AR (n = 12)	AR Rapa (n = 10)
Heart (mg)	1285 ± 45^a	1245 ± 31^a	1903 ± 63^b	1577 ± 52^c
Tibial length (mm)	57 ± 0.3^a	56 ± 0.4^b	58 ± 0.5^a	56 ± 0.3^b
Ind. Heart (mg/mm)	2.3 ± 0.07^a	2.2 ± 0.05^a	3.3 ± 0.09^b	2.8 ± 0.10^c
Left atria (mg)	29 ± 1.5^a	36 ± 2.1^a	55 ± 4.7^b	51 ± 5.9^b
Lungs (g)	2.9 ± 0.5^a	3.1 ± 0.5^a	3.4 ± 0.4^a	3.2 ± 0.4^a
Body weight (g)	564 ± 11.6^a	491 ± 11.3^b	562 ± 10.2^a	474 ± 14.4^b
EDD (mm)	8.6 ± 0.17^a	8.4 ± 0.16^a	11.0 ± 0.16^b	9.8 ± 0.12^c
ESD (mm)	4.1 ± 0.15^a	3.8 ± 0.18^a	6.3 ± 0.22^b	5.8 ± 0.20^b
SW (mm)	1.3 ± 0.04^a	1.4 ± 0.07^a	1.8 ± 0.05^b	1.6 ± 0.05^c
PW (mm)	1.4 ± 0.06^a	1.4 ± 0.06^a	1.8 ± 0.05^b	1.7 ± 0.08^b
EF (%)	78 ± 1.5^a	79 ± 1.8^a	68 ± 1.9^b	66 ± 1.6^b
AR (% reg.)	na	na	75 ± 4^a	71 ± 3^a

Number of animals per group in parentheses. Values are expressed as mean ± SEM. Means not sharing a common superscript are significantly different from each other, P < 0.05. Sham sham-operated animals and Rapa rapamycin. EDD: end-diastolic diameter, ESD end-systolic diameter, SW septal wall thickness, PW posterior wall thickness, EF ejection fraction, AR AR severity by echocardiographic semi-quantification and na non applicable