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Table 1 Animal characteristics and echocardiography data at the end of the protocol

From: Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation

Parameters Sham (n = 10) Sham Rapa (n = 9) AR (n = 12) AR Rapa (n = 10)
Heart (mg) 1285 ± 45a 1245 ± 31a 1903 ± 63b 1577 ± 52c
Tibial length (mm) 57 ± 0.3a 56 ± 0.4b 58 ± 0.5a 56 ± 0.3b
Ind. Heart (mg/mm) 2.3 ± 0.07a 2.2 ± 0.05a 3.3 ± 0.09b 2.8 ± 0.10c
Left atria (mg) 29 ± 1.5a 36 ± 2.1a 55 ± 4.7b 51 ± 5.9b
Lungs (g) 2.9 ± 0.5a 3.1 ± 0.5a 3.4 ± 0.4a 3.2 ± 0.4a
Body weight (g) 564 ± 11.6a 491 ± 11.3b 562 ± 10.2a 474 ± 14.4b
EDD (mm) 8.6 ± 0.17a 8.4 ± 0.16a 11.0 ± 0.16b 9.8 ± 0.12c
ESD (mm) 4.1 ± 0.15a 3.8 ± 0.18a 6.3 ± 0.22b 5.8 ± 0.20b
SW (mm) 1.3 ± 0.04a 1.4 ± 0.07a 1.8 ± 0.05b 1.6 ± 0.05c
PW (mm) 1.4 ± 0.06a 1.4 ± 0.06a 1.8 ± 0.05b 1.7 ± 0.08b
EF (%) 78 ± 1.5a 79 ± 1.8a 68 ± 1.9b 66 ± 1.6b
AR (% reg.) na na 75 ± 4a 71 ± 3a
  1. Number of animals per group in parentheses. Values are expressed as mean ± SEM. Means not sharing a common superscript are significantly different from each other, P < 0.05. Sham sham-operated animals and Rapa rapamycin. EDD: end-diastolic diameter, ESD end-systolic diameter, SW septal wall thickness, PW posterior wall thickness, EF ejection fraction, AR AR severity by echocardiographic semi-quantification and na non applicable