Fig. 2From: Tamoxifen-induced ovarian hyperstimulation during premenopausal hormonal therapy for breast cancer in Japanese womenInhibitory action of TAM on positive feedback to the hypothalamic-pituitary-axis by estrogen during the ovulatory phase. TAM can inhibit positive feedback to the hypothalamic-pituitary-axis by estrogen, leading to inhibition of the LH surge and then inducing the formation of a large follicular functional cystBack to article page