Fig. 1From: Tamoxifen-induced ovarian hyperstimulation during premenopausal hormonal therapy for breast cancer in Japanese womenInhibitory action of TAM on negative feedback to the hypothalamic-pituitary-axis by estrogen during the follicular phase. TAM can inhibit negative feedback to the hypothalamic-pituitary-axis by estrogen, leading to the increases of FSH and LH secretion by the pituitary gland and then inducing multiple follicular developmentBack to article page