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Table 1 Anticonvulsants per year

From: Novel way to investigate evolution of children refractory epilepsy by complexity metrics in massive information

Anticonvulsant

Year

Comments

Seizures

MSE

BMSE

IMI, PA

2006

First medicines consumed. Stopped suddenly

NA

NA

NA

VPA+, TPM, CLB, VPA

2007

Beginning of VA

NA

NA

NA

VPA, LTG, TPM, VPA+, CLB, LEV, ATX, ESM, PSE, MDZ

2008*

Pancreatitis. Beginning of ESM,LEV. ATX worsen seizures

\(\surd \)

OK

OK

TPM, LEV, LTG, PSE, ESM, CZP, ZNS

2009

ZNS useless. Retirement of ETS worsen seizures

NA

NA

NA

ZNS, ESM, CZP, LEV, CZP

2010*

CZP useless. Seizures worse

\(\times\)

Bad

Bad

CZP, LEV, LTG, ESM, PB

2011*

PB useless

\(\times \)

Bad

Bad

LCM, ESM, LEV, LTG, CZP

2012

LCM shows up.ETS retired again worsening seizures

NA

NA

NA

LCM, LEV, LTG, PRM, CZP, Q10, ESM

2013a*

Gastritis aggravate

\(\surd \)

OK

OK

LEV, ESM, LCM, LTG, CZP

2013b*

Idem

\(\surd \)

OK

OK

  1. \(\surd \) and \(\times \), a relative good and poor control of seizures, respectively; NA, not applicable.
  2. * an EEG was recorded in that year and is used in this work