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Table 2 Case–case comparison of receptor-positive vs. receptor-negative postmenopausal IDC breast cancer patients by quartiles of serum steroid concentrations

From: Serum estrone concentration, estrone sulfate/estrone ratio and BMI are associated with human epidermal growth factor receptor 2 and progesterone receptor status in postmenopausal primary breast cancer patients suffering invasive ductal carcinoma

Receptor status

Case–case study, odds ratio

E2 (pmol I−1)

E2/SHBG

E1 (pmol l−1)

E1S (pmol l−1)

E1S/E1

AD (nmol l−1)

TE (nmol l−1)

TE/SHBG

BMI (kg/m2)

(ER+)/(ER−)

0.82

1.09

1.66**

1.26

0.72

1.24

1.50

1.20

1.12

(PR+)/(PR−)

1.09

1.36

1.5*

1.08

0.65*

1.52*

1.36

1.39

1.66*

(ER+/PR+)/(ER−/PR−)

0.84

1.18

1.77*

1.23

0.66

1.31

1.56

1.29

1.70*

(HER2+)/(HER2−)

1.32

1.99

0.53*

2.44**

3.12***

0.81

0.99

1.04

0.48*

(HER2+/ER−/PR−)/(HER2−/ER−/PR−)

0.25

1.00

0.56

1.08

2.08

0.71

1.13

1.33

0.46

(HER2−/ER+/PR+)/(HER2−/ER+/PR−)

1.67

1.99

1.38

1.07

0.58

1.51

1.11

1.43

1.89

(HER2+/ER+/PR+)/(HER2−/ER−/PR−)

2.00

9.00*

1.50

17.00**

6.00*

2.14

11.60*

2.25

0.42

(HER2+/ER+/PR+)/(HER2−/ER+/PR+)

6.94

7.00

0.83

17.00*

31.19*

1.22

1.66

2.25

nd

  1. Odds ratios in the fourth quartile are shown. Rows in italics present comparisons where number of cases is small therefore these results are only informative. Further investigations are needed.
  2. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, E1 estrone, E1S estrone sulfate, E2 estradiol, TE testosterone, AD androstenedione, SHBG sex hormone binding globulin, BMI body mass index, OR odds ratio, nd no data.
  3. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001.