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Fig. 4 | SpringerPlus

Fig. 4

From: Serum estrone concentration, estrone sulfate/estrone ratio and BMI are associated with human epidermal growth factor receptor 2 and progesterone receptor status in postmenopausal primary breast cancer patients suffering invasive ductal carcinoma

Fig. 4

Case–case comparison of HER2-positive vs. HER2-negative postmenopausal IDC breast cancer patients by quartiles of serum steroid concentrations. Odds ratios (ORs) were computed taking the lowest category of hormone receptor-negative cases as reference. ORs with 95% CIs and Ptrend are presented by quartile limits of serum parameters. Black squares show ORs in quartiles (Q1–Q4), and the horizontal lines show 95% CIs. ORs are presented on a log scale. Chi-square test was used for determination of linear trends (Ptrend) among the groups classified by tumor receptor status. HER2 human epidermal growth factor receptor 2, E1 estrone, E1S estrone sulfate, E2 estradiol, TE testosterone, AD androstenedione, SHBG sex hormone binding globulin, BMI body mass index, OR odds ratio, CI confidence interval. Statistics: *p < 0.05, **p < 0.01, ***p < 0.001.

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