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Table 3 Toxicity, patient’s number (n = 31)

From: Combination chemotherapy with mitomycin C and methotrexate is active against metastatic HER2-negative breast cancer even after treatment with anthracycline, taxane, capecitabine, and vinorelbine

Toxicity

G1

%

G2

%

G3

%

G4

%

Thrombocytopenia

5

16.1

1

3.2

4

12.9

1

3.2

Leucopenia

3

9.7

7

22.6

2

6.5

2

6.5

Anemia

9

29.0

5

16.1

1

3.2

2

6.5

AST/ALT elevation

4

12.9

1

3.2

2

6.5

0

0

Anorexia

0

0.0

3

9.7

1

3.2

0

0

Neuropathy

2

6.5

4

12.9

1

3.2

0

0

Nausea

2

6.5

3

9.7

0

0

0

0

Vomiting

3

9.7

1

3.2

0

0

0

0

Constipation

4

12.9

0

0

0

0

0

0

Diarrhea

5

16.1

0

0

0

0

0

0

  1. G1-4 CTCAE grade 1–4.