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Table 1 Patient characteristics (n = 31)

From: Combination chemotherapy with mitomycin C and methotrexate is active against metastatic HER2-negative breast cancer even after treatment with anthracycline, taxane, capecitabine, and vinorelbine

Characteristics

Patients, n

%

Median age (range)

53 (30–75)

 

 Male

1

3.2

 Female

30

96.8

Performance status

 0

29

93.5

 1

2

6.5

ER/PgR status

 Positive/positive

15

48.4

 Positive/negative

6

19.4

 Negative/negative

10

32.3

No. of metastasis

 Median (range)

3 (1–5)

 

  1

5

16.1

  2

7

22.6

  3

15

48.4

  4

3

9.7

  5

1

3.2

Site of metastasis

 Lymph node

16

51.6

 Chest wall/skin

3

9.7

 Lung

16

51.6

 Pleura

3

9.7

 Bone

18

58.1

 Liver

18

58.1

 Contra late ral breast

1

3.2

 Muscle

1

3.2

 Peritoneum

2

6.5

No. of prior chemotherapy

 Median (range)

5 (5–8)

 

  5

19

61.3

  6

9

29.0

  7

1

3.2

  8

2

6.5

Agent used in prior chemotherapy

 CMF

4

12.9

 Anthracycline

31

100

 Taxane

31

100

  Paclitaxel

11

35.5

  Docetaxel

26

83.9

 Capecitabine

31

100

 Vinorelbine

31

100

 S-1

1

3.2

 UFT

3

9.7

 5-DFUR

1

3.2

 Other

1

3.2

  1. ER estrogen receptor, PR Progesterone receptor, CMF cyclophosphamide, methotrexate, and fluorouracil.