Table 3 Vancomycin dosing and monitoring parameters for those with culture-confirmed gram positive infections
From: Optimization of time to initial vancomycin target trough improves clinical outcomes
TDM (n = 66) | CTRL (n = 79) | P value | |
|---|---|---|---|
Reached Initial Target Trough, n (%) | 53 (80) | 33 (42) | <0.001 |
Time to Initial Target Trough (days), median (IQR) | 3 (2,3) | 5 (2,7) | <0.001 |
Initial target trough | |||
15–20 mg/L, n (%) | 33 (50) | 52 (66) | 0.1 |
10–15 mg/L, n (%) | 33 (50) | 27 (34) | 0.1 |
Loading dose, n (%) | 3 (5) | 0 | 0.54 |
Initial dose | |||
1.0 g q12hr, n (%) | 28 (42) | 63 (80) | <0.001 |
1.0 g q8hr, n (%) | 12 (18) | 1 (1) | 0.001 |
Other, n (%) | 26 (40) | 14 (19) | 0.005 |
No dose adjustment, n (%) | 21 (32) | 37 (48) | 0.06 |
Number of troughs drawn per patient, median (IQR) | 1 (1,4) | 2 (1,4) | 0.02 |
Mistimed troughs drawn per patient, median (IQR) | 0 (0,2) | 1 (0,2.5) | 0.002 |
Total VAN Dose (g), median (IQR) | 10 (7,20) | 11 (7,21) | 0.29 |