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Table 1 Summary of clinical presentation and laboratory investigation of coxsackievirus A6-associated HFMD cases

From: Unusual skin manifestation of hand, foot and mouth disease associated with coxsackievirus A6: cases report

Case

Sex

Age (years)

History of contact

Clinical manifestation

Laboratory investigation

Remarks

Oral

Hands/feet

Buttock

Unusual presentation

Tzanck smear

CA6-PCR

Throat swab

Stool

Vesicles/lesions

1

F

10 months

+

+

+

+

WAL, large vesicles

NA

+

NA

NA

 

2

M

1

+

+

+

WAL, large vesicles

NA

+

+

+

Desquamation

3

M

11 months

+

+

+

WAL, large vesicles

+

NA

+

Desquamation

4

F

10

+

Crust on scalp

NA

+

NA

+ (crust on scalp)

 

5

M

12

+

+

+

WAL, purpuric-like, crust on scalp

NA

+

NA

NA

Desquamation

6

F

2

+

+

+

GCS-like

NA

+

NA

NA

 

7

F

10

+

WTB, face (perioral), purpuric-like

+

+

NA

Underlying ALL, desquamation

8

M

10 months

+

+

GCS-like, face (perioral)

+

NA

 
  1. CA-6 coxsackievirus A6, F female, M male, NA not available, WAL widespread (arms, legs), GCS Gianotti–Crosti syndrome, WTB widespread (trunk, back).