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Table 1 Demographic and clinical characteristics of the March 2005–March 2010 Cohort

From: Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage

 

N = 2,801

N = 41

p value

No repeat craniotomy for post-operative hemorrhage

Repeat craniotomy for post-operative hemorrhage

Mean age, years (SD)

51.0 (16.0)

54.6 (15.5)

0.7

Male, n (%)

1,322 (47.4)

25 (62.5)

0.06

ASA grades 1–2, n (%)

1,236 (46.9)

20 (50.0)

0.82

ASA grades 3–5, n (%)

1,152 (53.1)

20 (50.0)

0.82

E Cases, n (%)

328 (12.1)

2 (5.0)

0.18

Tumor, n (%)

1,393 (49.7)

32 (80.0)

<0.0001

Vascular, n (%)

305 (10.9)

6 (15.0)

0.23

Trauma/other, n (%)

1,104 (39.5)

2 (5.0)

<0.0001

Baseline coagulopathy, n (%)

58 (2.1)

1 (2.5)

0.85

Mean EBL, mL (SD)

279.1 (391.9)

540.2 (1,176.2)

0.16

Mean operation length, min (SD)

229.2 (120.6)

226.3 (159.5)

0.15

Mean crystalloid volume, mL (SD)

2,694.9 (1909.5)

3,620.7 (2,351.1)

<0.0001

Received plasmanate*, n (%)

420 (14.7)

8 (19.5)

0.38

Mean plasmanate* volume, mL (SD)

529.7 (352.9)

750 (353.6)

0.21

Received hextend, n (%)

185 (6.6)

5 (12.5)

0.15

Mean hextend volume, mL (SD)

635.4 (286.9)

650 (335.4)

0.89

Received PRBCs, n (%)

194 (6.9)

3 (7.5)

0.89

Mean PRBCs volume, mL (SD)

877.5 (901.5)

2,450 (1,603.9)

0.003

Received FFP, n (%)

82 (2.9)

3 (7.5)

0.09

Mean FFP volume, mL (SD)

660.2 (603.0)

1,227 (1,050.7)

0.12

Received platelets, n (%)

91 (3.2)

1 (2.5)

0.77

Mean platelets volume, mL (SD)

353.0 (208.6)

563 (–)

  1. * Plasmanate is a purified plasma derivative consisting predominantly of human albumin.