Skip to main content
SpringerPlus

Table 5 Comparison of AST and ALT values in different administration routes

From: A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene

Administration

Enzyme activity (IU/L)

Day 1

Day 7

Day 14

Day 28

Day 42

Day 56

Day 71

AST

 Intravenous

801 ± 255

1,390 ± 492

644 ± 200

281 ± 81

   

 Intrapleural

  

214 ± 65

219 ± 38

202 ± 30

173 ± 23

169 ± 31

ALT

 Intravenous

356 ± 112

1,881 ± 648

1,031 ± 320

223 ± 62

   

 Intrapleural

  

361 ± 172

180 ± 63

205 ± 55

76 ± 12

65 ± 14

  1. Data show average and SE values (n = 5). CrlJ:CD1 mice injected with Ad-NK4 were 5-week old male. Data of untreated CrlJ:CD1 male mice at 11-week old (Japan Charles river, Japan) as follows.
  2. AST, 76 ± 11 IU/l; ALT, 32 ± 7 IU/l.
Back to article page