A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene

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Table 1 Complete blood counting data of mice injected with Ad-NK4 or PBS

Test	Day 1		Day 7		Day 14
Test	Ad-NK4	PBS	Ad-NK4	PBS	Ad-NK4	PBS
WBC (×10²/μl)	17 ± 2	23 ± 4	36 ± 10	20 ± 2	83 ± 26	27 ± 7
RBC (×10⁴/μl)	748 ± 20	674 ± 54	652 ± 32	736 ± 11	734 ± 32	713 ± 58
Hgb (g/dl)	13.3 ± 0.4	11.7 ± 0.7	11.2 ± 0.6	12.4 ± 0.1	12.6 ± 0.6	12.5 ± 0.7
Hct (%)	44.7 ± 1.2	40.2 ± 3.1	36.8 ± 2.0	40.8 ± 0.5	38.7 ± 1.8	37.8 ± 3.0
MCV (fl)	59.8 ± 0.4	59.7 ± 1.0	56.4 ± 1.1	55.4 ± 0.6	52.7 ± 0.1	53.0 ± 0.4
MCH (pg)	17.7 ± 0.2	17.4 ± 0.4	17.2 ± 0.4	16.9 ± 0.3	17.1 ± 0.1	17.7 ± 0.6
MCHC (%)	29.6 ± 0.2	29.1 ± 0.7	30.4 ± 0.4	30.4 ± 0.4	32.5 ± 0.1	33.3 ± 1.0
Plt (×10⁴/μl)	109.9 ± 12.0	67.9 ± 18.8	55.4 ± 14.6	49.3 ± 10.6	83.9 ± 34.4	48.2 ± 23.8

Data show average and SE values (n = 6). CrlJ:CD1 mice injected with Ad-NK4 were 5-week old male. Data of untreated CrlJ:CD1 male mice at 11-week old (Japan Charles river, Japan) as follows.
WBC, 20 ± 6.9 × 10²/μl; RBC, 943 ± 61 × 10⁴/μl; Hgb, 14.8 ± 1.0 g/dl; Hct, 45.3 ± 2.4%; MCV, 48.1 ± 1.9 fl; MCH, 15.7 ± 0.5 pg; MCHC, 32.6 ± 0.5%; Plt, 144.4 ± 18.9 × 10⁴/μl.