Table 1 Patients demographics and baseline features
From: Diagnostic value of the UCA1 test for bladder cancer detection: a clinical study
Overall patients (n = 161) | Screening group | Follow-up group | p value | ||
|---|---|---|---|---|---|
n = 79 | n = 83 | ||||
Clinical featuresa | |||||
Age (median (range)) | 68 (32–90) | 70 (35–90) | |||
Hematuria | 48 | 60.8% | 5 | 6% | p < 0.00001 |
Urinary tract infection | 8 | 10.1% | 1 | 1.2% | p = 0.01 |
Benign prostatic hyperplasia | 18 | 22.8% | 6 | 7.2% | p = 0.004 |
Renal transplant | 10 | 12.7% | 5 | 6% | p = 0.1 |
Lithiasis | 5 | 6.3% | 1 | 1.2% | p = 0.09 |
Hydronephrosis | 7 | 8.9% | 2 | 2.4% | p = 0.07 |
LUTS | 12 | 15.2% | 1 | 1.2% | p = 0.0009 |
Schistozomiasis | 2 | 2.5% | 0 | 0% | p = 0.24 |
Aristocholic acid nephropathy | 5 | 6.3% | 5 | 6% | p = 1 |
Other malignancies | 14 | 17.7% | 15 | 18.1% | p = 1 |
UCA1 test | p = 0.04 | ||||
Positive | 43 | 54.4% | 33 | 39.8% | |
Negative | 36 | 45.6% | 50 | 60.2% | |
Cytology | p = 0.09 | ||||
Positive | 21 | 26.6% | 14 | 16.9% | |
Negative | 49 | 62% | 59 | 71.1% | |
Unsatisfactory | 9 | 11.4% | 10 | 12% | |
Cystoscopy | p = 0.56 | ||||
Positive | 31 | 39.2% | 36 | 43.4% | |
Negative | 39 | 49.4% | 45 | 54.2% | |
Not performed | 9 | 11.4% | 2 | 2.4% | |
Histology | p = 0.56 | ||||
Benign | 12 | 15.2% | 15 | 18.1% | |
Malignant | 30 | 38% | 39 | 47% | |
Urothelial carcinoma | 27 | 38 | |||
Squamous carcinoma | 2 | 0 | |||
Adenocarcinoma | 0 | 1 | |||
Small cell carcinoma | 1 | 0 | |||
Not performed | 37 | 46.8% | 29 | 34.9% | |
Stage | |||||
pTis | 1 | 1.3% | 6 | 7.2% | |
pTa | 6 | 7.6% | 15 | 18% | |
pT1 | 9 | 11.8% | 6 | 7.2% | |
pT2 | 9 | 11.8% | 8 | 9.6% | |
pT3 | 4 | 5.1% | 1 | 1.2% | |
pT4 | 1 | 1.3% | 3 | 3.6% | |
Grade | |||||
PUNLMP | – | – | |||
Low grade | 7 | 8.9% | 16 | 19.3% | |
High grade | 19 | 24% | 16 | 19.3% | |
CIS | 1 | 1.3% | 6 | 7.2% | |
Not available | 3 | 3.8% | – | ||
Multicentricity | |||||
Single tumours | 16 | 20.2% | 20 | 24.1% | |
Multiple tumours | 10 | 12.6% | 11 | 13.6% | |
Not available | 4 | 5.1% | 1 | 1.2% | |